AUGUST 26. LONDON - Children’s Hospital Scientists have finally identified the gene that is responsible for the inherited adaptation of cancer neurblastoma in childhood.
The team that conducted the study was led by Yael P.Moss, pediatric oncologist of The Children’s Hospital of Philadelphia, with the use of speedy and automatic analytical equipment. The team found that a part of the chromosome 2 was partially related to the disease.
As the part was placed in sequence, it was seen that there was a mutation in the gene anaplastic lymphoma kinase (ALK) in 8 families with ancestral neuroblastoma.
Moss was quoted saying “This discovery enables us to offer the first genetic tests to families affected by the inherited form of this disease,” published the Nature Magazine.
Moss further added, “Furthermore, because there already is drugs in development that target the same gene in adult cancers, we can soon begin testing those drugs in children with neuroblastoma.”
After the ALK mutation detection in the ancestral (familial) neuroblastoma, the team then focused on the non-ancestral (non-familial) sporadic, which is more common, and they found the occurrence of ALK mutations in 12% of tumor samples out of 194. The samples were collected from aggressive and risky forms
of the disease.
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